The ANZGOG-led trial known as AtTEnd will engage patients with advanced endometrial cancer and will incorporate additional immune therapy into existing chemotherapy treatment.

Portrait of Yoland Antill

Dr. Yoland Antill

The coordinating Principal Investigator of the trial is Dr Yoland Antill, a medical oncologist based in Melbourne. Dr. Antill provided an explanation of the study, “for most women with endometrial cancer, immune therapy alone is not an effective way of treating endometrial cancer. The addition of chemotherapy may improve the chance of immune therapy stimulating the body’s own immune system to fight and destroy the cancer cells.”

The purpose of the study is to assess the benefit of immunotherapy drug atezolizumab, used in conjunction with the existing chemotherapy drugs carboplatin and paclitaxel.

“The addition of chemotherapy may improve the chance of immune therapy stimulating the body’s own immune system to fight and destroy the cancer cells.”

The trial is a Phase III study with two separate arms: two thirds of women will receive the additional immune therapy and one third will receive a placebo infusion. Neither the patient nor their treating doctor will know which arm of the study she has been randomised to, which is known as a blinded randomisation.

This trial will contribute to ANZGOG’s efforts to increase international collaborations with other research organisations, the trial will be conducted with the Mario Negri Gynaecologic Oncology group (MaNGO) part of the Mario Negri Institute for Pharmacological Research, based in Italy.

The AtTEnd Trial is planned to recruit from the following sites:

  • Border Medical Oncology – Albury
  • St George Hospital – Kogarah
  • Liverpool Hospital – Liverpool
  • Calvary Mater Newcastle – Waratah
  • Box Hill Hospital – Box Hill
  • Frankston Hospital – Frankston
  • Toowoomba Hospital – Toowoomba
  • Pindara Private Hospital – Benowa
  • Royal Brisbane & Womens Hospital – Herston
  • Icon Cancer Care South Brisbane – South Brisbane
  • The Royal Adelaide Hospital – Adelaide
  • Royal Hobart Hospital – Hobart
  • St John of God Hospital, Subiaco – Subiaco
  • Gosford Hospital, Gosford
  • Wollongong Hospital, Wollongong
  • Auckland City Hospital, Auckland

If you believe that you may be a suitable candidate, please speak to your Medical Oncologist about your eligibility.

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